李天虎（西北工业大学化学与化工学院教授） 0 0
李天虎，男，西北工业大学化学与化工学院教授。主要研究方向为生物有机化学/化学生物学、纳米材料的生物应用（upconverting nanoparticle、新型药物递送系统、肿瘤治疗、DNA nanogel等）、阐述真核生物染色体的三维结构和DNA超螺旋的关系。[1]-
中文名:李天虎 民族: 出生地: 毕业院校: 学位/学历: 职业:教师 专业方向: 职务:西北工业大学化学与化工学院教授 学术代表作: 主要成就:
人物经历
工作经历
2020.04至今 教授
研究方向：生物有机化学，化学生物学
西北工业大学化学与化工学院
2004-2008 副教授
研究方向：生物有机化学，化学生物学
新加坡国立大学化学系，新加坡
1996-1999 助理教授，化学系，The Scripps Research Institute ( under Professor K. C. Nicolaou’s domain ) , La Jolla, CA, USA
教育经历
1992-1994 美国斯克里普斯（The Scripps Research Institute）研究所化学系博士后
导师: KC尼古劳教授（Professor KC Nicolaou）
1987-1992 美国纽约州立大学石溪分校化学系获博士学位
导师: 史蒂芬罗基塔教授（Professor Steven E. Rokita）
1980-1982 北京化工大学高分子系获硕士学位
导师:金关泰教授
1977-1980 吉林大学化学系高分子专业本科毕业
主要成就
科研成果
拥有专利共计6项，过去十年从新加坡教育部、新加坡南洋理工大学等获得经费（共15次总和约四百六十万元新加坡币，折合人民币约二千三百万元）
发表文章
2篇发表在自然杂志上(影响因子: 41.577)
7篇在美国化学会志上 (影响因子: 14.357)
8 篇在德国应用化学上 (影响因子: 12.102)
3篇在纳米快报上 (影响因子: 12.080)
1 篇在核酸研究上 (影响因子: 11.561)
3 篇在Small上 (影响因子: 9.598)
1 篇在美国国家科学院院刊 (影响因子: 9.504)
1 篇在化学和生物学上 (影响因子: 6.743)
14 篇在化学通讯上 (影响因子: 6.290)
97. Ning Li, Feng Chen, Jie Shen, Hao Zhang, Tianxiang Wang, Ruijuan Ye, Tianhu Li, Teck Peng Loh, Yi Yan Yang, and Huaqiang Zeng*, Buckyball-Based Spherical Display of Crown Ethers for De Novo Custom Design of Ion Transport Selectivity, J. Am. Chem. Soc. 2020, 142, 50, 21082–21090.
96. Hao Zhang, Ruijuan Ye, Yuguang Mu, Tianhu Li, and Huaqiang Zeng*，Small Molecule-Based Highly Active and Selective K+ Transporters with Potent Anticancer Activities，2021，Nano Lett. 2021, 21, 3, 1384–1391.
95. Hao Zhang, Sai Ba, Jasmine Yiqin Lee, Jianping Xie, Teck-Peng Loh*, and Tianhu Li*，Cancer Biomarker-Triggered Disintegrable DNA Nanogels for Intelligent Drug Delivery，2020，Nano Lett. 2020, 20, 11, 8399–8407。
94. Zhang, Hao, Ba, Sai, Yang, Zhaoqi, Wang, Tianxiang, Lee, Jasmine,Li, Tianhu, Shao, Fangwei, Graphene Quantum Dot-Based Nanocomposites for Diagnosing Cancer Biomarker APE1 in Living Cells, 2020, ACS Applied Materials & Interfaces, 12, 12, 13634-13643
93. Zeng LZ, Zhang H, Wang T, Li T. Enhancing K transport activity and selectivity of synthetic K channels via electron-donating effects. Chemical Communications Chem Commun. 2020 56(8):1211-1214.
92. Aida Serra,Xavier Gallart-Palau, Wei Yi Koh, Zoey Jia Yu Chua,Xue Guo,Chase Jia Jing Chow,Wei Meng Chen,Jung Eun Park,Tianhu Li, James P.Tam,Siu Kwan Sze*, Prooxidant Modifications in the Cryptome of Beef Jerky, the Deleterious Post-Digestion Composition of Processed Meat Snacks, 2019, Food Res. Int., 125, 108569
91. Hao Zhang, Ruofan Li, Sai Ba, Zhaoyong Lu, Emmanuel N. Pitsinos*, Tianhu Li*, K. C. Nicolaou*, DNA Binding and Cleavage Modes of Shishijimicin A, 2019, J. Am. Chem. Soc. 141, 19, 7842-7852.
90. Hao Zhang, Tianhu Li*, Mechanistic Analyses of Supercoiling Behaviors of DNA in Nucleosomes and Chromatins, 2019, bioRxiv, Preprint, https://doi.org/10.1101/523084 (https://www.biorxiv.org/content/early/2019/01/17/523084)
89. Hao Zhang, Tianhu Li*, New Supercoiling Theory and Model of Chromosomal Structures in Eukaryotic Cells, 2018, ChemRxiv, Preprint, http://doi.org/10.26434/chemrxiv.7415207.v1
88. Hao Zhang, Sai Ba, Divyanshu Mahajan, Jasmine Yiqin Lee, Ruijuan Ye, Fangwei Shao, Lei Lu*, Tianhu Li*, Versatile Types of DNA-Based Nanobiosensors for Specific Detection of Cancer Biomarker FEN1 in Living Cells and Cell-Free Systems, 2018, Nano Lett., 18(11), 7383-7388
87. Hao Zhang, Tianhu Li*, Dataset on the effects of spermidine on linking number differences between histoneH1-free and histone H1-bound circular polynucleosomes, 2018, Data in Brief, 17, 709-715
86. Hao Zhang, Tianhu Li*,Quantitative determination of linking number differences between circular polynucleosomes and histone H1-bound circular polynucleosomes,2018, Bioorganic & Medicinal Chemistry Letters, 28, 537–540.
85. Hao Zhang, Tianhu Li*, Effects of spermidine and ATP on stabilities of chromatosomes and histone H1-depleted chromatosomes, 2017, Bioorganic & Medicinal Chemistry Letters, 27 (5), 1149-1153
84. He L, Meng Z, Chen X, Li T, Shao F* "Aza-bridged bisphenanthrolinyl Pt(II) complexes: efficient stabilization and topological selectivity on telomeric G-quadruplexes" J. Inorg. Biochem 2017, 166, 135-140
83. Hao Zhang, Tianhu Li*, Presence of negative supercoiling in aggregates of histone H1-plasmidic polynucleosome complexes, 2016, Bioorganic & Medicinal Chemistry Letters, 27(2), 168–170
82. Vicky Ziman Zeng, Haibin Su and Tianhu Li*,Computation-guided improved one-pot synthesis of macrocyclic cation-binding aromatic pyridone pentamers, 2016, Organic & Biomolecular Chemistry, 14, 9961-9965
81. Lei He, Xiang Chen, Zhenyu Meng, Jintao Wang, Keyin Tian, Tianhu Li and Fangwei Shao, Octahedral ruthenium complexes selectively stabilize G-quadruplexes, 2016, Chemical Commun., 52, 8095-8098
80. Gitali Devi, Lei He, Baochang Xu, Tianhu Li and Fangwei Shao*, In-stem thiazole orange reveals the same triplex intermediate for pH and thermal unfolding of i-motifs, 2016, Chemical Commun., 52, 7261-7264
79. Haixia Wu, Wei Chen, Hui Yang, Suhua Wang, Si Ting Lim, Wei Yao, Juanjuan Guo, Tianhu Li, Ming Wah Wong, Dejian Huang, Improved synthesis dimethylhomoecoerdianthrone (HOCD) and itsfunctionalization through facile amination reactions, 2016, Dyes and Pigments, 130, 154 -161
78. Sai Ba, Hao Zhang, Yiqin Jasmine Lee, Haixia Wu, Ruijuan Ye, Dejian Huang and Tianhu Li*, Investigation of human flap structure-specific endonuclease 1 (FEN1) activity on primer- template models and exploration of a substratebased FEN1 inhibitor, 2016, Bioorganic & Medicinal Chemistry, 24(9), 1988-1992
77. Qiong Lei, Sai Ba, Hao Zhang, Yanyan Wei, Jasmine Yiqin Lee, Tianhu Li*, Enrichment of omega-3 fatty acids in cod liver oil via alternate solvent winterization and enzymatic interesterification, 2016, Food Chemistry, 199, 364–371
76. Sai Ba, Hao Zhang, Yiqin Jasmine Lee, Chee Wee Ng and Tianhu Li*, Chemical modifications of ricinolein in castor oil and methyl ricinoleate for viscosity reduction to facilitate their use as biodiesels, 2015, European Journal of Lipid Science and Technology, 118(4), 651-657
75. Zhang, Hao; Ba, Sai; Co, Sarajane Co; Lee, Jasmine Yiqin; Guo, Juanjuan; Ye, Ruijuan; Liang, Zhaoxun; Huang, Dejian; Li, Tianhu*, An alternative method for evaluating stabilities of DNA hairpin structures, 2015, The Bulletin of the Chemical Society of Japan, 88(9), 1314-1316
74. Qiong Lei, Tianhu Li*, Functional monoesters of jojoba oil can be produced by enzymatic interestification: Reaction analysis and structural characterization, 2015, European Journal of Lipid Science and Technology, 117, 630-636
73. Li, D. W.; Lv, B.; Zhang, H.; Li, Y. Q. J; Li, T. H.*, Disintegration of cruciform and G-quadruplex structures during the course of helicase-dependent amplification (HDA), 2015, Bioorg Med Chem Lett,, 25, 1709–1714
72. Dawei Li, Bei Lv, Hao Zhang, Jasmine Yiqin Lee and Tianhu Li*, Positive supercoiling affiliated with nucleosome formation repairs non-B DNA structures, 2014, Chemical Commun., 50, 10641-10644
71. Li, Cheng; Sun, Jingcan; Li, Tianhu; Liu, Shao-Quan; Huang, Dejian, Chemical and enzymatic synthesis of a library of 2-phenethyl esters and their sensory attributes, 2014, Food Chemistry, 154, 205-210
70. Li, Cheng; Sun, Jingcan; Fu, Caili; Yu, Bin; Liu, Shao Quan; Li, Tianhu; Huang, Dejian, Synthesis and evaluation of odour-active methionyl esters of fatty acids via esterification and transesterification of butter oil, 2014, Food Chemistry, 145, 796-801
69. Bei Lv, Dawei Li, Hao Zhang, Jasmine Yiqin Lee and Tianhu Li*, DNA gyrase-driven generation of a G-quadruplex from plasmid DNA, 2013, Chem. Commun.,49, 8317-8319
68. Sai Ba, Qiong Lei, Chee Wee Ng, Hao Zhang, Dejian Huang, Tianhu Li*, Synthesis of New Types of Brominated Diesters as Potential Food Emulsifiers, 2013, GSTF International Journal of Chemical Sciences, 1(1), 40-47
67. Hao Zhang, Juanjuan Guo, Dawei Li, Magdeline Tao Tao Ng, Jasmine Yiqin Lee, Bei Lv, Chee Wee Ng, Selvi Lee, Fangwei Shao, Tianhu Li*, Confirmation of quinolone-induced formation of gyrase–DNA conjugates using AFM, 2013, Bioorganic & Medicinal Chemistry Letters, 23, 4622-4626
66. Qiong Lei, Wilson Liangwei Lee, Tianhu Li*, Design and synthesis of 1,3-dicapryloyl-2-acetylglycerol as molecular probe for TAG metabolism study, European Journal of Lipid Science and Technology, 2013, 115 (2), 232-238
65. Xu, W., Xie, X., Li, D., Yang, Z., Li, T., Liu, X., Ultrasensitive colorimetric DNA detection using a combination of rolling circle amplification and nicking endonuclease-assisted nanoparticle amplification (NEANA), Small, 2012, 8 (12), 1846-1850
64. Hong Kee Tan, Dawei Li, Robert Kenneth Gray, Zhaoqi Yang, Magdeline Tao Tao Ng, Hao Zhang, Joel Ming Rui Tan, Shuhui Hiew, Jasmine Yiqin Lee and Tianhu Li*, Interference of intrinsic curvature of DNA by DNA-intercalating agents , Org. Biomol. Chem., 2012, 10, 2227-2230
63. Yang, Z.Q., Li, D.W., Guo, J.J., Shao,F.W, Li, T.H*, Intrinsic curvature in duplex DNA inhibits Human Topoisomerase I.,2012,Bioorganic & Medicinal Chemistry Letters 22, 1322-1325
62. Li, D., Yang, Z., Lv, B., Li, T.*, Observation of backbone self-crossings of organismal DNAs through atomic force microscopy., 2012, Bioorg. Med. Chem. Lett., 22, 833-836
61. Yifan Wang, Ruoyu Zhan, Tianhu Li, Kan-Yi Pu, Yanyan Wang, Yoke Cheng Tan, and Bin Liu, Fluorescence and Visual Detection of Single Nucleotide Polymorphism using Cationic Conjugated Polyelectrolyte, Langmuir, 2012, 28(1), 889-895
60. Zhaoqi Yang, Dawei Li and Tianhu Li*, Design and synthesis of catenated rings based on toroidal DNA structures, Chem. Commun., 2011, 47, 11930-11932
59. Zhaoqi Yang, Dawei Li, Shuhui Hiew, Magdeline Taotao Ng, Weixing Yuan, Haibin Su, Fangwei Shao and Tianhu Li, Recognition of forcible curvature in circular DNA by human topoisomerase I, Chem. Commun., 2011, 47, 11309-11311
58. Dawei Li, Zhaoqi Yang, Yi Long, Guanjia Zhao, Bei Lv, Shuhui Hiew, Magdeline Tao Tao Ng, Juanjuan Guo, HongKee Tan, Hao Zhang, Weixing Yuan, Haibin Su and Tianhu Li, Precise engineering and visualization of signs and magnitudes of DNA writhe on the basis of PNA invasion. Chem. Commun., 2011, 47, 10695-10697
57. Wang, Hongbo; Xu, Wei; Zhang, Hao; Li, Dawei; Yang, Zhaoqi; Xie, Xiaoji; Li, Tianhu; Liu, Xiaogang. EcoRI-Modified Gold Nanoparticles for Dual-Mode Colorimetric Detection of Magnesium and Pyrophosphate Ions, Small, 2011, 7(14), 1987-1992
56. Li, Dawei; Yang, Zhaoqi; Zhao, Guanjia; Long, Yi; Lv, Bei; Li, Cheng; Hiew, Shuhui; Ng, Magdeline Tao Tao; Guo, Juanjuan; Tan, Hong Kee; Zhang, Hao; Li, Tianhu. Manipulating DNA writhe through varying DNA sequences, Chemical Communications (Cambridge, United Kingdom), 2011, 47(26), 7479-7481
55. Xie, Xiaoji; Xu, Wei; Li, Tianhu; Liu, Xiaogang. Colorimetric Detection of HIV-1 Ribonuclease H Activity by Gold Nanoparticles. Small, 2011, 7(10), 1393-1396
54. Wong, W. C.; Zhuang, J. Y.; Ng, S. L. L.; New, L. L. L.; Hiew, S.; Guo, J. J.; Yang, Z. Q.; Li, T. H., Conformational organizations of G-quadruplexes composed of d(G(4)T(n))(3)G(4). Bioorganic & Medicinal Chemistry Letters, 2010, 20, (15), 4689-4692
53. Xu, W.; Xue, X. J.; Li, T. H.; Zeng, H. Q.; Liu, X. G., Ultrasensitive and Selective Colorimetric DNA Detection by Nicking Endonuclease Assisted Nanoparticle Amplification. Angewandte Chemie-International Edition 2009, 48, (37), 6849-6852
52. Ng, M. T. T.; Li, X. M.; Wang, Y. F.; Zhou, T. Y.; Yang, Z. Q.; Foo, H. Y.; Li, T. H., Site- Specific Cleavage of G-quadruplexes Formed by Oxytricha Telometric Repeats. Australian Journal of Chemistry 2009, 62, (9), 1189-1193
51. Chua, S. T.; Quek, N. M.; Li, M.; Ng, M. T. T.; Yuan, W. X.; Chua, M. L.; Guo, J. J.; Koh, L. E.; Ye, R. J.; Li, T. H., Nick-containing oligonucleotides as human topoisomerase I inhibitors. Bioorganic & Medicinal Chemistry Letters 2009, 19, (3), 618-623
50. Zhou, T. Y.; Li, X. M.; Ng, M. T. T.; Wang, Y. F.; Quek, N. M.; Luo, J.; Yuan, W. X.; Tan, C. H.; Zeng, H. Q.; Li, T. H., Synthesis and Characterization of Circular Structures of i-Motif Tagged with Fluoresceins. Bioconjugate Chemistry 2009, 20, (4), 644-647
49. Li, X. M.; Ng, M. T. T.; Wang, Y. F.; Zhou, T. Y.; Chua, S. T.; Yuan, W. X.; Li, T. H., Site-specific self-cleavage of G-quadruplexes formed by human telemetric repeats. Bioorganic & Medicinal Chemistry Letters 2008, 18, (20), 5576-5580
48. Wang, Y. F.; Ng, M. T. T.; Zhou, T. Y.; Li, X. M.; Tan, C. H.; Li, T. H., C3-Spacer-containing circular oligonucleotides as inhibitors of human topoisomerase I. Bioorganic & Medicinal Chemistry Letters 2008, 18, (12), 3597-3602
47. Liu, X. Q.; Li, X. M.; Zhou, T. Y.; Wang, Y. F.; Ng, M. T. T.; Xu, W.; Li, T. H., Site specific self-cleavage of certain assemblies of G-quadruplex. Chemical Communications 2008, (3), 380-382
46. Wang, Y. F.; Li, X. M.; Liu, X. Q.; Li, T. H., An i-motif-containing DNA device that breaks certain forms of Watson-crick interactions. Chemical Communications 2007, (42), 4369-4371
45. Li, X. M.; Ng, M. T. T.; Wang, Y. F.; Liu, X. Q.; Li, T. H., Dumbbell-shaped circular oligonucleotides as inhibitors of human topoisomerase I. Bioorganic & Medicinal Chemistry Letters 2007, 17, (17), 4967-4971
44. Zhou, T. Y.; Wang, Y. F.; Li, X. M.; Zhang, Q.; Li, T. H., Synthesis and characterization of a fluorescein-labeled circular G-quadruplex. Bull. Chem. Soc. Jpn. 2006, 79, (8), 1300-1302
43. Zhou, T. Y.; Chen, G. S.; Wang, Y. F.; Zhang, Q.; Yang, M.; Li, T. H., Synthesis of unimolecularly circular G-quadruplexes as prospective molecular probes. Nucleic Acids Res. 2004, 32, (21)
42. Liu, D. S.; Chen, J.; Lee, A. H. F.; Chow, L. M. C.; Chan, A. S. C.; Li, T. H., Small circular oligodeoxynucleotides achieved from self-assembling entities. Angewandte Chemie-International Edition 2003, 42, (7), 797-799
41. Qi, J. Y.; Li, T. H.; Chan, A. S. C., Fungicide chinomethionate as a new family of photoinducible DNA-cleaving agents. Bioorganic & Medicinal Chemistry Letters 2003, 13, (20), 3561-3563
40. Lee, A. H. F.; Chan, A. S. C.; Li, T. H., Synthesis of 5-(7-hydroxyhept-3-enyl)-1,2-dithiolan-3-one 1-oxide, a core functionality of antibiotic leinamycin. Tetrahedron 2003, 59, (6), 833-839
39. Lee, A. H. F.; Chen, J.; Chan, A. S. C.; Li, T. H., Synthesis of 5-(7-hydroxyheptyl)1,2- dithiolan-3-one 1-oxide, a core functionality of antibiotic leinamycin. Phosphorus Sulfur Silicon Relat. Elem. 2003, 178, (5), 1163-1174
38. Lee, A. H. F.; Chen, J.; Liu, D. S.; Leung, T. Y. C.; Chan, A. S. C.; Li, T. H., Acid-promoted DNA-cleaving activities and total synthesis of varacin C. Journal of the American Chemical Society 2002, 124, (47), 13972-13973
37. Lee, A. H. F.; Chan, A. S. C.; Li, T. H., Acid-accelerated DNA-cleaving activities of antitumor antibiotic varacin. Chemical Communications 2002, (18), 2112-2113
36. Chen, J.; Liu, D. S.; Lee, A. H. F.; Qi, J. Y.; Chan, A. S. C.; Li, T. H., G-quadruplex as a new class of structural entities for directing the formation of circular oligodeoxyribonucleotides. Chemical Communications 2002, (22), 2686-2687
35. Lee, A. H. F.; Chan, A. S. C.; Li, T. H., Benzotrithiole 2-oxide: A new family of thiol-activated DNA-cleaving functionalities. Bioorganic & Medicinal Chemistry Letters 2002, 12, (22), 3259-3261
34. Lee, A. H. F.; Zhou, Z. Y.; Li, T. H.; Chan, A. S. C., Varacinium chloride. Acta Crystallogr. Sect. E.-Struct Rep. Online 2002, 58, O465-O466
33. Li, T. H.; Liu, D. S.; Chen, J.; Lee, A. H. F.; Qi, J. Y.; Chan, A. S. C., Construction of circular oligodeoxyribonucleotides on the new structural basis of i-motif. Journal of the American Chemical Society 2001, 123, (51), 12901-12902
32. Nicolaou, K. C.; Pfefferkorn, J.; Xu, J. Y.; Winssinger, N.; Ohshima, T.; Kim, S. H.; Hosokawa, S.; Vouruloumis, D.; van Delft, F.; Li, T., Total synthesis and chemical biology of the sarcodictyins. Chem. Pharm. Bull. 1999, 47, (9), 1199-1213
31. Nicolaou, K.C.; Winssinger, N.; Vourloumis, D.; Ohshima, T.; Kim, S.; Pfefferkorn, J.; Xu, J.-Y.; Li, T.; Hosokawa, S., Total synthesis of sarcodictyins A and B: Solid- and solution- phase synthesis and biological evaluation of combinatorial sarcodictyin libraries. Chemtracts 1999, 12, (14), 1006-1012
30. Couladouros, E. A.; Li, T. H.; Moutsos, V. I.; Pitsinos, E. N.; Soufli, I. C., Stabilization of microtubules by combretastatin D derivatives. Bioorganic & Medicinal Chemistry Letters 1999, 9, (20), 2927-2928
29. Nicolaou, K. C.; Winssinger, N.; Vourloumis, D.; Ohshima, T.; Kim, S.; Pfefferkorn, J.; Xu, J. Y.; Li, T., Solid and solution phase synthesis and biological evaluation of combinatorial sarcodictyin libraries. Journal of the American Chemical Society 1998, 120, (42), 10814- 10826
28. Nicolaou, K. C.; He, Y.; Roschangar, F.; King, N. P.; Vourloumis, D.; Li, T. H., Total synthesis of epothilone E and analogues with modified side chains through the Stille coupling reaction. Angewandte Chemie-International Edition 1998, 37, (1-2), 84-87
27. Nicolaou, K. C.; Kim, S. H.; Pfefferkorn, J.; Xu, J. Y.; Ohshima, T.; Hosokawa, S.; Vourloumis, D.; Li, T. H., Synthesis and biological activity of sarcodictyins. Angewandte Chemie-International Edition 1998, 37, (10), 1418-1421
26. Nicolaou, K. C.; Finlay, M. R. V.; Ninkovic, S.; King, N. P.; He, Y.; Li, T. H.; Sarabia, F.; Vourloumis, D., Synthesis and biological properties of C12,13-cyclopropylepothilone a and related epothilones. Chemistry & Biology 1998, 5, (7), 365-372
25. Plyta, Z. F.; Li, T. H.; Papageorgiou, V. P.; Mellidis, A. S.; Assimopoulou, A. N.; Pitsinos, E. N.; Couladouros, E. A., Inhibition of topoisomerase I by naphthoquinone derivatives. Bioorganic & Medicinal Chemistry Letters 1998, 8, (23), 3385-3390
24. Li, T. H.; Nadin, A., Correlation between time reversal symmetry and chirality in certain molecular processes. Chirality 1998, 10, (4), 289-293
23. Nicolaou, K. C.; Winssinger, N.; Pastor, J.; Ninkovic, S.; Sarabia, F.; He, Y.; Vourloumis, D.; Yang, Z.;Li, T(李天虎).; Giannakakou, P.; Hamel, E., Synthesis of epothilones A and B in solidand solution phase.Nature (自然)1997, 387, (6630), 268-272
22. Nicolaou, K. C.; Winssinger, N.; Pastor, J.; Ninkovic, S.; Sarabia, F.; He, Y.; Vourloumis, D.; Yang, Z.; Li, T.; Giannakakou, P.; Hamel, E., Synthesis of epothilones A and B in solid and solution phase (vol 387, pg 268, 1997). Nature 1997, 390, (6655), 100-100
21. Nicolaou, K. C.; Vourloumis, D.; Li, T. H.; Pastor, J.; Winssinger, N.; He, Y.; Ninkovic, S.; Sarabia, F.; Vallberg, H.; Roschangar, F.; King, N. P.; Finlay, M. R. V.; Giannakakou, P.; VerdierPinard, P.; Hamel, E., Designed epothilones: Combinatorial synthesis, tubulin assembly properties, and cytotoxic action against taxol-resistant tumor cells. Angewandte Chemie-International Edition 1997, 36, (19), 2097-2103
20. Nicolaou, K. C.; Ninkovic, S.; Finlay, M. R. V.; Sarabia, F.; Li, T. H., Total synthesis of 26-hydroxyepothilone B and related analogues. Chemical Communications 1997, (24), 2343- 2344
19. Nicolaou, K. C.; vanDelft, F.; Ohshima, T.; Vourloumis, D.; Xu, J. Y.; Hosokawa, S.; Pfefferkorn, J.; Kim, S.; Li, T. H., Total synthesis of eleutherobin. Angewandte Chemie-International Edition 1997, 36, (22), 2520-2524
18. Li, T. H.; Weinstein, D. S.; Nicolaou, K. C., The chemical end-ligation of homopyrimidine oligodeoxyribonucleotides within a DNA triple helix. Chemistry & Biology 1997, 4, (3), 209-214
17. Lazo, J. S.; Li, T. H.; Woo, E. S.; Settineri, C. E.; Allan, W. P.; Yalowich, J. C., Chemical synthesis and biological activity of a novel fluorescent etoposide derivative. Biochem. Pharmacol. 1997, 53, (5), 715-722
16. Liu, C.; Smith, B. M.; Ajito, K.; Komatsu, H.; GomezPaloma, L.; Li, T. H.; Theodorakis, E. A.; Nicolaou, K. C.; Vogt, P. K., Sequence-selective carbohydrate DNA interaction: Dimeric and monomeric forms of the calicheamicin oligosaccharide interfere with factor function. Proceedings of the National Academy of Sciences of the United States of America 1996, 93, (2), 940-944
15. Nicolaou, K. C.; Ajito, K.; Komatsu, H.; Smith, B. M.; Li, T. H.; Egan, M. G.; Gomezpaloma, L., DNA-carbohydrate recognition-design and synthesis of an 8-base sequence-selective DNA-binding oligosaccharide. Angewandte Chemie-International Edition 1995, 34, (5), 576-578
14. Li, T.; Nadin, A., Theoretical aspects of time-reversal symmetry violation in ring current molecules. Phys. Lett. A 1995, 206, (3-4), 222-224
13. Li, T.（李天虎，第一作者）; Nicolaou, K. C., Chemical self-replication of palindromic duplex DNA. Nature （自然）1994,369, (6477), 218-221
12. Li, T. H.; Zeng, Q. P.; Rokita, S. E., Target-promoted alkylation of DNA. Bioconjugate Chemistry 1994, 5, (6), 497-500
11. Li, T. H.; Zeng, Z. J.; Estevez, V. A.; Baldenius, K. U.; Nicolaou, K. C.; Joyce, G. F., carbohydrate minor-groove interactions in the binding of calicheamicin gamma-1(i) to duplex DNA. Journal of the American Chemical Society 1994, 116, (9), 3709-3715
10. Nicolau, K.C.; Li, T.; Nakada, M.;Hummel, C.W.; Wrasidlo, W., Calicheamicin Theta(I)(1)- A Rationally Designed Molecule with Extremely Potent And Selective DNA-Cleaving Properties and Apoptosis Inducing Activity, Angewandte Chemie-Edition, 1994, 33, (2), 183-186
9. Li, T. H., a possible role of molecular decay in the origin of asymmetric emergence of biomolecules on earth. J. Theor. Biol. 1994,170, (2), 227-230
8. Jin, G. T.; Yang, W.; Li, T.; Sheng, C.; Hu, Y.; Phenomenon and theory of ionic-bond gel. Huaxue Tongbao1993, 1, 17-21
7. Jin, G. T.; Li, T. H. Some theoretical problems of anionic polymerization of butadiene. XIII. A study on pseudo-gel formation in the preparation of hydroxyl-terminated polybutadiene. J. Polym. Mater.1992, 9, (1), 49-54
6. Li, T. H.; Rokita, S. E., selective modification of dna controlled by an ionic signal. Journal of the American Chemical Society 1991, 113, (20), 7771-7773
5. Jin, G. T.; Li, T. H., Some theoretical problems of anionic polymerization of butadiene. IX. A study on functionalization of polybutadienyllithium terminated by triazine chloride and hydrolysis of its end-product. J. Polym. Mater.1990, 7, (2), 105-13
4. Jin, G.T.; Li, T.H., Some theoretical problems of anionic polymerization of butadiene. 1. Polymerization mechanism and derivation of the relationship between vinyl content and THF concentration. J. Polym. Mater.1987, 4, (1), 41-50
3. Jin, G.T.; Li, T.H., Preparation of telechelic cyanuric acid-terminated polybutadiene-1,2. Gaodeng Xuexiao Huaxue Xuebao1985, 6, (9), 848-50
2. Jin, G.T.; Li, T.H., Effect of tetrahydrofuran additive on anionic polymerization of butadiene. Huagong Xuebao1985, 2, 215-24
1. Jin, G.T.; Li, T.H., "Pseudo-gel" formation in the preparation of hydroxyl-terminated polybutadiene. (I). Gaodeng Xuexiao Huaxue Xuebao 1985, 6, (1), 82-6.
人才培养
过去10年内教过的课程（共6类课程）:
1. 有机化学类 (3门不同的课程)：研究生有机合成（博士生）、高级有机合成和光谱学(本科生)、光谱在有机化学中的应用（本科生）
2. 生物化学类：生物化学（本科生）
3. 食品科学类（2门不同的课程）食品化学和营养学（本科生）、食品加工和防腐（本科生）
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人物：何小鹏简介
人物：孟晚舟简介
王亚平